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Invitrogen
Invitrogen CD197 (CCR7) Monoclonal Antibody (3D12), PE eBioscience
Invitrogen CD197 (CCR7) Monoclonal Antibody (3D12), PE eBioscience
$422.95
- MFR:
- 12197942
- Medex SKU:
- IVT-12-1979-42
- Packing Info:
- 1/Each
- Usually Ships:
- 3 - 5 Business Days
- Freight Quote Button:
- False
Description
The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding.