Exela Pharma Sciences
Description
Active Ingredient: Sodium Bicarbonate (NaHCO₃) at an 8.4% concentration, which is equivalent to 1 mEq/mL.
Prefilled Syringe Format: The medication comes in a 50 mL Luer-Jet prefilled syringe, designed for single-dose injection. This format is intended for quick and easy use, particularly in emergency situations, as it eliminates the need for manual preparation from vials.
Preservative-Free: The solution contains no bacteriostatic or antimicrobial agents, making it suitable for patients who may be sensitive to these substances.
Sterile and Nonpyrogenic: It is a sterile, hypertonic solution in water for injection, meaning it is free from microorganisms and fever-inducing substances.
Alkalizing Agent: The primary function of the drug is to increase the body's plasma bicarbonate, buffer excess hydrogen ions, raise the blood pH, and reverse the clinical signs of acidosis.
Sodium Bicarbonate 8.4% Injection is a critical medication used in a variety of acute and emergency medical situations. Its primary uses include:
Metabolic Acidosis: It is indicated for the treatment of metabolic acidosis that can arise from severe conditions such as:
Uncontrolled diabetes (diabetic ketoacidosis)
Severe renal disease
Circulatory insufficiency due to shock or dehydration
Severe primary lactic acidosis
Cardiac Arrest: It is used as an adjunctive therapy during cardiopulmonary resuscitation (CPR) to help correct the severe metabolic acidosis that occurs during cardiac arrest.
Drug Intoxications: The medication can be used in the treatment of certain drug poisonings, such as with barbiturates or salicylates, where the alkalinization of the urine helps to increase drug excretion.
Severe Diarrhea: It is also indicated in cases of severe diarrhea, which can lead to a significant loss of bicarbonate from the body.
Alkalinization of Urine: The medication can be used to alkalinize the urine to help diminish the nephrotoxicity (kidney damage) caused by hemoglobin and its breakdown products in hemolytic reactions.